The efficacy of Amomum villosum porridge

The effects of Amomum villosum porridge can be summarized into the following three points. Let’s take a look at the details below.

The effect of Amomum villosum porridge

1. Effects on the digestive system: 1.1. Effects on isolated intestinal smooth muscle: A section of rat, guinea pig or rabbit small intestine was placed in a Tyrode's solution bath, and the changes in intestinal activity were recorded by a recorder to observe the effects of the drug solution on the spontaneous activity of the intestinal tube and the antagonism of acetylcholine and BaCl2. Results: When the decoction of Amomum villosum (2.5-5×10(-3)g crude drug/ml) was used, the contraction of the small intestine of guinea pigs and rats was strengthened. When the dose was increased, it had an inhibitory effect on the intestine, showing a decrease in tension and a decrease in amplitude. The decoction of Amomum villosum had a partial inhibitory effect on the tension and tonic contraction of the small intestine of rats caused by acetylcholine and barium chloride. The volatile part of Amomum villosum (1.3×l0(-3)g crude drug/ml) could cause mild excitement in the rabbit intestine, and then turn into a significant inhibitory effect, with reduced tension, slower contraction frequency, and reduced amplitude. Depending on the concentration, it could partially or completely antagonize the excitement or spasm of the intestine caused by acetylcholine and BaCl2. 1.2. Effect on intestinal propulsion: Mice weighing 20-24g were randomly divided into two groups. The treatment group was given Amomum villosum decoction (0.5g/kg), and the control group was given distilled water. The length of the intestinal segment reached by the charcoal powder/the percentage of the entire intestine was measured to measure the functional state of intestinal propulsion. The results showed that the treatment group was 82.2±4.4%, compared with the control group (62.5±2.9), P<0.01, indicating that Amomum villosum can promote intestinal motility.

Effects of Amomum villosum porridge

2. Effect on platelet aggregation function: Rabbits weighed (2.0-2.6kg), 3-4 rabbits in each group, the administration group was divided into two dose groups, oral administration of Amomum villosum 0.6 and 1.2g/kg, respectively, and the control group was oral administration of the same dose of solvent. Blood was collected from the carotid artery 15, 30, 60, and 90 minutes after administration, and PRP and PPP were prepared by centrifugation. The platelet aggregation rate (%) was measured on a platelet aggregometer using ADP as an aggregation agent. The results showed that Amomum villosum could significantly inhibit platelet aggregation (see Table 6)

The effect of Amomum villosum porridge

3. Effect on acute death of mice induced by arachidonic acid: Mice (weight 20-22g), 10 mice in each group, two groups were orally administered with 0.6 and 1.2g/kg of Amomum villosum, respectively, and the control group was orally administered with an equal volume of solvent. Arachidonic acid was injected intravenously 1.5 hours after administration, and the death of mice within 15 minutes was observed. Results: 2 and 1 mice died in the two groups administered with 0.6 and 1.2g/kg, respectively, compared with the control group (7 deaths), P < 0.001, indicating that Amomum villosum has a significant protective effect on acute death of mice induced by arachidonic acid.