The efficacy of Gardenia kernel porridge

The efficacy of Gardenia kernel porridge

Oral administration of Gardenia water extract and alcohol extract to rabbits had no effect on the amount of bile and solid content of bile derived from the bile duct. However, some people injected the same preparation into rabbits, and bile secretion began to increase after 15 to 30 minutes and lasted for more than 1 hour. After intravenous injection of crocin and sodium crocetin to rabbits, bile secretion increased. After oral administration of Gardenia water decoction or mixed preparation to people, gallbladder film was taken, which proved that the gallbladder had a significant contraction effect 20 and 40 minutes after taking the medicine. After the total bile duct of rabbits was ligated, oral administration of Gardenia water extract reduced blood bilirubin. The more the drug was taken, the more significant the reduction was (if it was taken orally once every 24 hours after ligation, the result was very obvious). Especially after continuous administration of appropriate amount of drugs and ligation, the best effect was obtained. Alcohol extract also had the same effect, but it was slightly weaker than water extract. After injection of gardenia alcohol extract into rabbits, blood bilirubin increased slightly compared with the control group 2 hours later, decreased compared with the control group 6 hours later, and significantly decreased after 24 to 48 hours. Crocin and sodium crocetin also had the same effect. In rabbits with common bile duct ligation, injection of alcohol extract reduced bilirubin in peripheral lymph fluid 24 hours later. Crocin and sodium crocetin also had the same effect. Gardenia can be used for jaundice caused by biliary inflammation.

②Sedative and antihypertensive effects

Subcutaneous injection of Gardenia fluid extract in mice reduced spontaneous activity, closed eyes, lowered heads, and relaxed muscles. It could counteract the convulsions of pentylenetetrazol, but not strychnine, but could reduce mortality. The above effects were not observed when the ash of fluid extract was used as a control. It is also useful for eliminating insomnia and excessive fatigue. Gardenia decoction and alcohol extract have a persistent hypotensive effect on cats, rats and rabbits, whether taken orally or injected intraperitoneally. The hypotensive effect is rapid but short-lived, and the hypotensive site seems to be in the parasympathetic center of the medulla oblongata.

③ Antimicrobial effect

Gardenia water solution has inhibitory effects on various fungi such as Trichophyton, Epidermophyton inguinale, Epidermophyton rubrum, etc. in the test arm. Its water decoction 15 mg/ml can kill Leptospira. In vitro, Gardenia decoction can stop the activity of Schistosoma japonicum, and the decoction has no inhibitory effect on bacterial growth.

④Other functions

Gardenia alcohol extract has a low-concentration excitatory effect on the isolated intestinal smooth muscle of rabbits and rats, while a high-concentration one inhibits it. Dehydroxygariposide has a laxative effect on mice, and its extract made into an ointment can accelerate the healing of soft tissues.

[Toxicity] The median lethal dose for acute intraperitoneal injection in mice is 27.45 g/kg, and for subcutaneous injection is 31.79 g/kg. Compared with the effective sedative dose, the safety index is smaller.

[Processing] Raw Gardenia: sieve out the ash, pick out the impurities, crush and sieve; or cut off the two ends. Gardenia kernel: take the clean gardenia, cut it in half with scissors, peel off the skin and take out the kernel. Gardenia peel: the outer peel of raw gardenia. Stir-fried Gardenia: take the crushed gardenia, put it in a pot and stir-fry it over low heat until golden yellow, take it out and let it cool. Scorched Gardenia: take the crushed gardenia, put it in a pot and stir-fry it over high heat until it is burnt, take it out and let it cool. Gardenia charcoal: take the crushed gardenia, put it in a pot and stir-fry it over high heat until it is dark brown, but it must be preserved, take it out and let it cool.

"Leigong Paozhi Lun" says: "When using Gardenia, first remove the skin and beard, take the fruit, soak it in liquorice water overnight, filter it out, dry it, pound it and sieve it until it becomes red gold powder before use."